Co-opting signalling molecules enables logic-gated control of CAR T cells
Tousley AM, Rotiroti MC, Labanieh L, Rysavy LW, Kim WJ, Lareau C, Sotillo E, Weber EW, Rietberg SP, Dalton GN, Yin Y, Klysz D, Xu P, de la Serna EL, Dunn AR, Satpathy AT, Mackall CL, Majzner RG
Nature
March 2023
Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
Christian L Flugel, Robbie G Majzner, Giedre Krenciute, Gianpietro Dotti, Stanley R Riddell, Dimitrios L Wagner, Mohamed Abou-El-Enein
Nature Reviews Clinical Oncology
November 2022
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Mabe NW, Huang M, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG.
Nature Cancer
August 2022
Immunotherapy of Neuroblastoma: Facts and Hopes
John Anderson, Robbie G Majzner, Paul M Sondel
Clinical Cancer Research
August 2022
Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Louai Labanieh, Robbie G Majzner, Dorota Klysz, Elena Sotillo, Chris J Fisher, José G Vilches-Moure, Kaithlen Zen B Pacheco, Meena Malipatlolla, Peng Xu, Jessica H Hui, Tara Murty, Johanna Theruvath, Nishant Mehta, Sean A Yamada-Hunter, Evan W Weber, Sabine Heitzeneder, Kevin R Parker, Ansuman T Satpathy, Howard Y Chang, Michael Z Lin, Jennifer R Cochran, Crystal L Mackall
Cell
May 2022
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication
Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, Lattin J, Xu P, Huang J, Nasholm N, He A, Kuo TC, Sangalang ERB, Pons J, Barkal A, Brewer RE, Marjon KD, Vilches-Moure JG, Marshall PL, Fernandes R, Monje M, Cochran JR, Sorensen PH, Daldrup-Link HE, Weissman IL, Sage J, Majeti R, Bertozzi CR, Weiss WA, Mackall CL, Majzner RG.
Nature Medicine
February 2022
In vivo imaging of nanoparticle-labeled CAR T cells
Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolás Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, Michael Eugene Moseley, Robbie G Majzner, Heike Elisabeth Daldrup-Link
PNAS
February 2022
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
Sabine Heitzeneder, Kristopher R Bosse, Zhongyu Zhu, Doncho Zhelev, Robbie G Majzner, Molly T Radosevich, Shaurya Dhingra, Elena Sotillo, Samantha Buongervino, Guillem Pascual-Pasto, Emily Garrigan, Peng Xu, Jing Huang, Benjamin Salzer, Alberto Delaidelli, Swetha Raman, Hong Cui, Benjamin Martinez, Scott J Bornheimer, Bita Sahaf, Anya Alag, Irfete S Fetahu, Martin Hasselblatt, Kevin R Parker, Hima Anbunathan, Jennifer Hwang, Min Huang, Kathleen Sakamoto, Norman J Lacayo, Dorota D Klysz, Johanna Theruvath, José G Vilches-Moure, Ansuman T Satpathy, Howard Y Chang, Manfred Lehner, Sabine Taschner-Mandl, Jean-Phillipe Julien, Poul H Sorensen, Dimiter S Dimitrov, John M Maris, Crystal L Mackall
Cancer Cell
January 2022
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
Jay Y Spiegel, Shabnum Patel, Lori Muffly, Nasheed M Hossain, Jean Oak, John H Baird, Matthew J Frank, Parveen Shiraz, Bita Sahaf, Juliana Craig, Maria Iglesias, Sheren Younes, Yasodha Natkunam, Michael G Ozawa, Eric Yang, John Tamaresis, Harshini Chinnasamy, Zach Ehlinger, Warren Reynolds, Rachel Lynn, Maria Caterina Rotiroti, Nikolaos Gkitsas, Sally Arai, Laura Johnston, Robert Lowsky, Robbie G Majzner, Everett Meyer, Robert S Negrin, Andrew R Rezvani, Surbhi Sidana, Judith Shizuru, Wen-Kai Weng, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Magali Bazzano, Jing Zhou, Sean Mackay, Scott J Bornheimer, Liora Schultz, Sneha Ramakrishna, Kara L Davis, Katherine A Kong, Nirali N Shah, Haiying Qin, Terry Fry, Steven Feldman, Crystal L Mackall, David B Miklos
Nature Medicine
August 2021
